Education & Research  |   Medical Residency Program  |   Medical Physics Program  |   Therapy Programs Research  |   Publications

Below is a list of departmental publications, sorted by year. Find the PubMed abstract by clicking on the link. From within PubMed, OSU users may also link to the full text article (where available) by clicking either the OhioLINK EJC or OLinks button located on the right side of the page.

2007 Publications

Lo SS, Chang EL, Yamada Y, Sloan AE, Suh JH, Mendel E. Stereotactic radiosurgery and radiation therapy for spinal tumors. Expert Rev Neurother. 2007 Jan;7(1):85-93. Review.

A description and summary of clinical applications of stereotactic radiosurgery and radiotherapy for spinal tumors.

Fakiris AJ, Lo SS, Henderson MA, Witt TC, Worth RM, Danis RP, Des Rosiers PM, Timmerman RD. Gamma-knife-based stereotactic radiosurgery for uveal melanoma. Stereotact Funct Neurosurg. 2007;85(2-3):106-12.

A clinical study showing that Gamma-Knife-based stereotactic radiosurgery provides excellent local control of uveal melanoma.

Henderson MA, Valluri S, Lo SS, Witt TC, Worth RM, Danis RP, Timmerman RD. Gamma knife radiosurgery in the treatment of choroidal neovascularization (wet-type macular degeneration). Stereotact Funct Neurosurg. 2007;85(1):11-7.

A clinical study indicating that Gamma-Knife radiosurgery may be useful as a salvage treatment for patients with macular degeneration.

Nagda SN, Mohideen N, Lo SS, Khan U, Dillehay G, Wagner R, Campbell S, Flanigan R. Long-term follow-up of (111)In-capromab pendetide (ProstaScint) scan as pretreatment assessment in patients who undergo salvage radiotherapy for rising prostate-specific antigen after radical prostatectomy for prostate cancer. Int J Radiat Oncol Biol Phys. 2007 Mar 1;67(3):834-40.

A clinical study showing that capromab pendetide scan has low predictive value in patients with rising PSA after radical prostatetomy.

Hoopes DJ, Tann M, Fletcher JW, Forquer JA, Lin PF, Lo SS, Timmerman RD, McGarry RC. FDG-PET and stereotactic body radiotherapy (SBRT) for stage I non-small-cell lung cancer. Lung Cancer. 2007 May;56(2):229-34. Epub 2007 Mar 13.

A clinical evaluation showing that FDG-PET scan is effective in detecting disease progression in lung cancer patients in prospective clinical trials using stereotactic body radiotherapy.

Gao M, Wang JZ, Nag, S, Gupta N. Effects of seed migration on post-implant dosimetry of prostate brachytherapy. Med Phys. 2007 Feb;34(2):471-80.

This study developed a computer code to simulate seed migration in prostate brachytherapy, analyzed the dosimetric changes due to seed migration, and discussed its potential impact on post-implant quality evaluation and treatment outcome.

2006 Publications

Wang JZ, Li XA, Mayr NA. Dose escalation to combat hypoxia in prostate cancer: a radiobiological study on clinical data. Br J Radiol. 2006 Nov;79(947):905-11.

This study uses a mathematical model to analyze clinical data to provide a preliminary estimate of the prescription dose needed to overcome tumor hypoxia.

Lo SS, Abdulrahman R, Desrosiers PM, Fakiris AJ, Witt TC, Worth RM, Dittmer PH, Desrosiers CM, Frost S, Timmerman RD. The role of Gamma Knife Radiosurgery in the management of unresectable gross disease or gross residual disease after surgery in ependymoma. J Neurooncol. 2006 Aug;79(1):51-6.

This clinical study concludes that Gamma-Knife-based stereotactic radiosurgery provides reasonable local control and is a feasible and safe treatment for ependymoma.

Mayr NA, Yuh WT, Taoka T, Wang JZ, Wu DH, Montebello JF, Meeks SL, Paulino AC, Magnotta VA, Adli M, Sorosky JI, Knopp MV, Buatti JM. Serial therapy-induced changes in tumor shape in cervical cancer and their impact on assessing tumor volume and treatment response. AJR Am J Roentgenol. 2006 Jul;187(1):65-72.

This study analyzes therapy-induced changes in tumor shape as seen in MR imaging of cervical tumors and suggests that region-of-interest-based volumetry offers a better means of assessing tumor response.

Zhang H, Johnson EL, Zwicker RD. Dosimetric validation of the MCNPX Monte Carlo simulation for radiobiologic studies of megavoltage grid radiotherapy. Int J Radiat Oncol Biol Phys. 2006 Dec 1;66(5):1576-83.

 An analysis of MCNPX Monte Carlo simulation of dose profiles in grid therapy concludes that this treatment modality is more suitable for treating acutely responding tumors and radiosensitive normal tissues.

Wang JZ, Mayr NA, Nag S, Montebello J, Gupta N, Samsami N, Kanellitsas C. Effect of edema, relative biological effectiveness, and dose heterogeneity on prostate brachytherapy. Med Phys. 2006 Apr;33(4):1025-32.

This study uses mathematical modeling to analyze the factors influencing tumor response to LDR brachytherapy and evaluated the effects of edema, RBE, and dose heterogeneity on radiobiological modeling of prostate cancer.

Mayr NA, Lo SS, Grecula J, Wang J, Zhang H, Montebello J, Martin D, Yuh WT. Tumor imaging: radiation oncology perspective. Top Magn Reson Imaging. 2006 Apr;17(2):117-9. Review.

Ross P Jr, Grecula J, Bekaii-Saab T, Villalona-Calero M, Otterson G, Magro C. Incorporation of photodynamic therapy as an induction modality in non-small
cell lung cancer. Lasers Surg Med. 2006 Dec;38(10):881-9.

Use of photodynamic therapy to treat  non-small cell lung cancer is shown to be safe and may improve patient status sufficiently to allow other treatment modalities to be used.

Li JC, Mayr NA, Yuh WT, Wang JZ, Jiang GL. Cranial nerve involvement in nasopharyngeal carcinoma: response to radiotherapy and its clinical impact. Ann Otol Rhinol Laryngol. 2006 May;115(5):340-5.

This report analyzes the factors that influence the neurologic outcome of radiotherapy and the patterns and time course of neurologic recovery from cranial nerve palsy and concludes that timely diagnosis and rapid institution of therapy are essential.

Ozer E, Grecula JC, Agrawal A, Rhoades CA, Schuller DE. Intensification regimen for advanced-stage resectable hypopharyngeal carcinoma. Arch Otolaryngol Head Neck Surg. 2006 Apr;132(4):385-9.

The intensification regimen described in this prospective phase II clinical trial, combining surgery, radiation therapy, and chemotherapy (cisplatin and paclitaxel) along with intraoperative radiation therapy, accomplished excellent long-term survival and disease control rates in 32 patients with advanced resectable hypopharyngeal carcinoma.

Ozer E, Grecula JC, Agrawal A, Rhoades CA, Young DC, Schuller DE. Long-term results of a multimodal intensification regimen for previously untreated advanced resectable squamous cell cancer of the oral cavity, oropharynx, or hypopharynx. Laryngoscope. 2006 Apr;116(4):607-12.

This phase II clinical trial treating advanced resectable squamous cell cancer of the head and neck with preoperative accelerated hyperfractionated radiotherapy, concurrent chemotherapy followed immediately by surgery and intraoperative radiotherapy, and completed with postoperative chemotherapy and concurrent radiotherapy and concluded that this regimen achieved excellent locoregional and systemic disease control.

Yuh WT, Mayr NA. Central nervous system tumor: advance imaging and multispecialty approach. Top Magn Reson Imaging. 2006 Apr;17(2):51-2.

Wang D, Grecula JC, Gahbauer RA, Schuller DE, Jatana KR, Biancamano JD, Lang JC. p16 gene alterations in locally advanced squamous cell carcinoma of the head and neck. Oncol Rep. 2006 Mar;15(3):661-5.

This study of the mutational status of p16 in locally advanced squamous cell carcinoma of the head and neck concluded that regardless of the frequent presence of  p16 alterations in squamous cell carcinoma of the head and neck, p16 alterations alone do not appear to be associated with clinical outcome.

Mardirossian G, Hall M, Montebello J, Stevens P. Dose distribution to spinal structures from intrathecally administered yttrium-90. Phys Med Biol. 2006 Jan 7;51(1):185-96. Epub 2005 Dec 15.

Monte Carlo N-particle (MCNP4C) analysis was used to model Y-90 and I-131 radiation distribution in a phantom; Y-90 was found to be preferable to I-131 as a radionuclide for delivery by monoclonal antibodies.

Li JC, Hu CS, Jiang GL, Mayr NA, Wang JZ, He XY, Wu YR. Dose escalation of three-dimensional conformal radiotherapy for locally recurrent nasopharyngeal carcinoma: a prospective randomised study. Clin Oncol (R Coll Radiol). 2006 May;18(4):293-9.

This prospective randomised study of thirty-six patients with recurrent nasopharyngeal carcinoma found that re-irradiation with high-dose boost technique results in improved recurrence-free survival.

Henderson MA, Shirazi H, Lo SS, Mendonca MS, Fakiris AJ, Witt TC, Worth RM, Timmerman RD. Stereotactic radiosurgery and fractionated stereotactic radiotherapy in the treatment of uveal melanoma. Technol Cancer Res Treat. 2006 Aug;5(4):411-9. Review.

A literature review of stereotactic radiotherapy techniques in the treatment of primary intraocular malignant tumors.

Johnson BE, Crawford J, Downey RJ, Ettinger DS, Fossella F, Grecula JC, Jahan T, Kalemkerian GP, Kessinger A, Koczywas M, Langer CJ, Martins R, Marymont MH, Niell HB, Ramnath N, Robert F, Williams CC Jr; National Comprehensive Cancer Network (NCCN). Small cell lung cancer clinical practice guidelines in oncology. J Natl Compr Canc Netw. 2006 Jul;4(6):602-22.

Wu DH, Mayr NA, Karatas Y, Karatas R, Adli M, Edwards SM, Wolff JD, Movahed A, Montebello JF, Yuh WT. Interobserver variation in cervical cancer tumor delineation for image-based radiotherapy planning among and within different specialties. J Appl Clin Med Phys. 2005 Fall;6(4):106-10.

This study systematically describes differences in interpretation of imaging studies used in the treatment of cervical cancer.

Nag S, Koc M, Schuller DE, Tippin D, Grecula JC. Intraoperative single fraction high-dose-rate brachytherapy for head and neck cancers. Brachytherapy. 2005;4(3):217-23.

This clinical study of intraoperative high-dose-rate brachytherapy for head and neck cancers found that this modality can be used to effectively and safely treat sites inaccessible to intraoperative electron beam therapy.

Lo SS, Chang EL, Suh JH. Stereotactic radiosurgery with and without whole-brain radiotherapy for newly diagnosed brain metastases. Expert Rev Neurother. 2005 Jul;5(4):487-95. Review.

A literature review of the advantages and disadvantages of stereotactic radiosurgery and whole-brain radiotherapy in the treatment of brain metastases.

Li XA, Wang JZ, Jursinic PA, Lawton CA, Wang D. Dosimetric advantages of IMRT simultaneous integrated boost for high-risk prostate cancer. Int J Radiat Oncol Biol Phys. 2005 Mar 15;61(4):1251-7.

This propsective study explored the feasibility of using IMRT simultaneous integrated boost (SIB) to deliver high dose to the prostate and lower dose to the pelvic nodes simultaneously. The proposed SIB technique offers potential advantages of better sparing of critical structures, more efficient delivery, shorter treatment duration, and better biologic effectiveness.

Koc M, McGregor J, Grecula J, Bauer CJ, Gupta N, Gahbauer RA. Gamma Knife radiosurgery for intracranial metastatic melanoma: an analysis of survival and prognostic factors. J Neurooncol. 2005 Feb;71(3):307-13.

This retrospective study of twenty-six patients with intracranial metastatic melanoma identifies favorable prognostic factors for survival

This clinical study describes a method of adapting a treatment procedure to account for a retroverted uterus and thereby allowing effective brachytherapy treatment for cervical cancer.

Wang JZ, Li XA. Impact of tumor repopulation on radiotherapy planning. Int J Radiat Oncol Biol Phys. 2005 Jan 1;61(1):220-7.

This study provides a preliminary estimate of the dose escalation to offset the accelerated tumor cell repopulations during prolonged treatment courses for prostate cancer, based on the in situ measurements of potential tumor doubling time and radiobiologic models.

Li XA, Wang JZ. Repair of unacceptable implants. In Mundt AJ, Roeske JC, editors. Intensity modulated radiation therapy: A clinical perspective. Ontario, Canada: BC Decker Inc., 2005.

Arthur G. James Cancer Hospital and Richard J. Solove Research Institute Department of Radiation Medicine 300 West 10th Avenue   •   Columbus, OH 43210 Phone: (614) 293-8415   •   FAX: (614) 293-4044 Patient Scheduling: (614) 293-3241 ©2007 The Ohio State University Medical Center. This Web site is an informational service and is not intended to replace your doctor. Please consult your physician or call The James Line at 1-800-293-5066 with any questions or concerns. All material is the property of OSU Medical Center. All rights reserved. Please see our disclaimer for more detail. DHTML Web Menu by OpenCube